“Diffuse Large B-cell Lymphoma Pipeline Insight, 2024“ report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Diffuse Large B-cell Lymphoma Market.
The Diffuse Large B-cell Lymphoma Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.
Some of the key takeaways from the Diffuse Large B-cell Lymphoma Pipeline Report:
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Companies across the globe are diligently working toward developing novel Diffuse Large B-cell Lymphoma treatment therapies with a considerable amount of success over the years.
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Diffuse Large B-cell Lymphoma companies working in the treatment market are Ubix Therapeutics, Otsuka Pharmaceutical Co., Ltd, Biomea Fusion Inc, Autolus Limited, Xynomic Pharmaceuticals, Inc., Hanmi Pharmaceutical, S IMV Inc. Seagen Inc., Zai Lab, Genentech, and others, are developing therapies for the Diffuse Large B-cell Lymphoma treatment
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Emerging Diffuse Large B-cell Lymphoma therapies in the different phases of clinical trials are- UBX-303, OPB-111077, BMF-219, AUTO3, Abexinostat, Poseltinib, Maveropepimut, Brentuximabvedotin, Odronextamab, Mosunetuzumab, and others are expected to have a significant impact on the Diffuse Large B-cell Lymphoma market in the coming years.
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In June 2024, Pfizer Inc. (NYSE: PFE) reported detailed overall survival (OS) results from the Phase 3 ECHELON-3 study of ADCETRIS® (brentuximab vedotin) combined with lenalidomide and rituximab for relapsed/refractory diffuse large B-cell lymphoma (DLBCL). The study indicated that this combination reduced the risk of death by 37% compared to a placebo combined with lenalidomide and rituximab (HR 0.63 [95% CI: 0.445-0.891], p=0.0085). The OS benefit was consistent across all levels of CD30 expression. These results will be presented as a late-breaking abstract (LBA7005) at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, alongside four-year results from the Phase 3 HD21 trial in advanced classical Hodgkin lymphoma (cHL) (LBA7000).
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In April 2024, Roche has disclosed findings from the Phase III STARGLO trial demonstrating that its treatment Columvi (glofitamab), in combination with gemcitabine and oxaliplatin (GemOx), enhanced overall survival (OS) in patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL). This multicenter, open-label, randomized study evaluated the safety and effectiveness of Columvi plus GemOx versus MabThera/Rituxan (rituximab) combined with GemOx.
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In March 2024, GenFleet Therapeutics has entered into a clinical trial collaboration and supply agreement with BeiGene Switzerland to initiate a Phase Ib/II clinical trial combining GFH009 and BRUKINSA (zanubrutinib) for the treatment of diffuse large B cell lymphoma (DLBCL). GFH009 is a cyclin-dependent kinase 9 (CDK9) inhibitor developed by GenFleet, while BRUKINSA is a Bruton’s tyrosine kinase (BTK) inhibitor from BeiGene.
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In Aug23, Prelude Therapeutics is doing clinical testing on PRT-2527, which is now in Phase I for Diffuse Large B-Cell Lymphoma. GlobalData estimates that a 78% phase transition success rate (PTSR) indication threshold is required for Phase I medications for diffuse large B-cell lymphoma to advance to Phase II.
Diffuse Large B-cell Lymphoma Overview
Diffuse Large B-cell Lymphoma (DLBCL) is a type of non-Hodgkin lymphoma, which is a cancer that originates in the lymphatic system. DLBCL specifically affects B-cells, a type of white blood cell crucial for the immune system. It is called “diffuse” because the cancerous B-cells grow rapidly and can spread throughout the lymphatic system and sometimes beyond.
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Emerging Diffuse Large B-cell Lymphoma Drugs Under Different Phases of Clinical Development Include:
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UBX-303: Ubix Therapeutics
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OPB-111077: Otsuka Pharmaceutical Co., Ltd
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BMF-219: Biomea Fusion Inc
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AUTO3: Autolus Limited
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Abexinostat: Xynomic Pharmaceuticals, Inc.
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Poseltinib: Hanmi Pharmaceutical
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Maveropepimut: S IMV Inc.
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Brentuximabvedotin: Seagen Inc.
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Odronextamab: Zai Lab
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Mosunetuzumab: Genentech
Diffuse Large B-cell Lymphoma Route of Administration
Diffuse Large B-cell Lymphoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as
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Oral
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Parenteral
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Intravenous
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Subcutaneous
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Topical.
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Molecule Type
Diffuse Large B-cell Lymphoma Molecule Type
Diffuse Large B-cell Lymphoma Products have been categorized under various Molecule types, such as
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Monoclonal Antibody
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Peptides
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Polymer
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Small molecule
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Gene therapy
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Product Type
Diffuse Large B-cell Lymphoma Pipeline Therapeutics Assessment
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Diffuse Large B-cell Lymphoma Assessment by Product Type
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Diffuse Large B-cell Lymphoma By Stage and Product Type
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Diffuse Large B-cell Lymphoma Assessment by Route of Administration
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Diffuse Large B-cell Lymphoma By Stage and Route of Administration
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Diffuse Large B-cell Lymphoma Assessment by Molecule Type
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Diffuse Large B-cell Lymphoma by Stage and Molecule Type
DelveInsight’s Diffuse Large B-cell Lymphoma Report covers around 75+ products under different phases of clinical development like
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Late-stage products (Phase III)
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Mid-stage products (Phase II)
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Early-stage product (Phase I)
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Pre-clinical and Discovery stage candidates
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Discontinued & Inactive candidates
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Route of Administration
Further Diffuse Large B-cell Lymphoma product details are provided in the report. Download the Diffuse Large B-cell Lymphoma pipeline report to learn more about the emerging Diffuse Large B-cell Lymphoma therapies
Some of the key companies in the Diffuse Large B-cell Lymphoma Therapeutics Market include:
Key companies developing therapies for Diffuse Large B-cell Lymphoma are – AstraZeneca, Bristol-Myers Squibb, Seattle Genetics/Takeda, ADC Therapeutics, SymBio Pharmaceuticals, Denovo Biopharma, Merck, Amgen, TG Therapeutics, Bayer and others.
Diffuse Large B-cell Lymphoma Pipeline Analysis:
The Diffuse Large B-cell Lymphoma pipeline report provides insights into
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The report provides detailed insights about companies that are developing therapies for the treatment of Diffuse Large B-cell Lymphoma with aggregate therapies developed by each company for the same.
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It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Diffuse Large B-cell Lymphoma Treatment.
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Diffuse Large B-cell Lymphoma key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
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Diffuse Large B-cell Lymphoma Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
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Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Diffuse Large B-cell Lymphoma market.
The report is built using data and information traced from the researcher’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.
Download Sample PDF Report to know more about Diffuse Large B-cell Lymphoma drugs and therapies
Diffuse Large B-cell Lymphoma Pipeline Market Drivers
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Increasing Prevalence of DLBCL, increased research and development and CAR-T therapies are some of the important factors that are fueling the Diffuse Large B-cell Lymphoma Market.
Diffuse Large B-cell Lymphoma Pipeline Market Barriers
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However, high cost of treatment, aggressive disease biology and geriatric vulnerability and other factors are creating obstacles in the Diffuse Large B-cell Lymphoma Market growth.
Scope of Diffuse Large B-cell Lymphoma Pipeline Drug Insight
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Coverage: Global
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Key Diffuse Large B-cell Lymphoma Companies: Ubix Therapeutics, Otsuka Pharmaceutical Co., Ltd, Biomea Fusion Inc, Autolus Limited, Xynomic Pharmaceuticals, Inc., Hanmi Pharmaceutical, S IMV Inc. Seagen Inc., Zai Lab, Genentech, and others
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Key Diffuse Large B-cell Lymphoma Therapies: UBX-303, OPB-111077, BMF-219, AUTO3, Abexinostat, Poseltinib, Maveropepimut, Brentuximabvedotin, Odronextamab, Mosunetuzumab, and others
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Diffuse Large B-cell Lymphoma Therapeutic Assessment: Diffuse Large B-cell Lymphoma current marketed and Diffuse Large B-cell Lymphoma emerging therapies
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Diffuse Large B-cell Lymphoma Market Dynamics: Diffuse Large B-cell Lymphoma market drivers and Diffuse Large B-cell Lymphoma market barriers
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Table of Contents
1. Diffuse Large B-cell Lymphoma Report Introduction
2. Diffuse Large B-cell Lymphoma Executive Summary
3. Diffuse Large B-cell Lymphoma Overview
4. Diffuse Large B-cell Lymphoma- Analytical Perspective In-depth Commercial Assessment
5. Diffuse Large B-cell Lymphoma Pipeline Therapeutics
6. Diffuse Large B-cell Lymphoma Late Stage Products (Phase II/III)
7. Diffuse Large B-cell Lymphoma Mid Stage Products (Phase II)
8. Diffuse Large B-cell Lymphoma Early Stage Products (Phase I)
9. Diffuse Large B-cell Lymphoma Preclinical Stage Products
10. Diffuse Large B-cell Lymphoma Therapeutics Assessment
11. Diffuse Large B-cell Lymphoma Inactive Products
12. Company-University Collaborations (Licensing/Partnering) Analysis
13. Diffuse Large B-cell Lymphoma Key Companies
14. Diffuse Large B-cell Lymphoma Key Products
15. Diffuse Large B-cell Lymphoma Unmet Needs
16 . Diffuse Large B-cell Lymphoma Market Drivers and Barriers
17. Diffuse Large B-cell Lymphoma Future Perspectives and Conclusion
18. Diffuse Large B-cell Lymphoma Analyst Views
19. Appendix
20. About DelveInsight
About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.
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