DelveInsight’s “Cholestatic Pruritus Pipeline Insights, 2021” report provides detailed insights into the Cholestatic Pruritus market’s current clinical development status and growth prospects. The disease summary and Cholestatic Pruritus therapy guidelines are included in a complete description of the Cholestatic Pruritus pipeline environment.
Some Key Highlights from the Cholestatic Pruritus Pipeline Report
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Mirum Pharmaceuticals, GlaxoSmithKline, CymaBay Therapeutics, Cara Therapeutics, Escient Pharmaceuticals are among the notable companies who are testing their drug candidates in the Cholestatic Pruritus treatment market.
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Pipeline therapy for Cholestatic Pruritus such as LUM001 (Mirum Pharmaceuticals) is in the pre-registration phase.
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Some pipeline therapies for Cholestatic Pruritus such as GSK2330672 and Seladelpar are in the Phase III of development while pipeline therapy like Korsuva is in Phase II of clinical trials.
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Pipeline therapy such as EP 547 is still in the early stage of development i.e. Phase I of clinical trials for Cholestatic Pruritus.
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Cholestatic Pruritus: Disease Overview
Cholestasis is a reduction in bile flow caused by decreased hepatocyte secretion or obstruction of bile flow through intra- or extrahepatic bile ducts. This bile secretion problem occurs somewhere between the liver cells that make bile and the duodenum (the first segment of the small intestine).
Furthermore, both intrahepatic cholestasis and extrahepatic biliary blockage can cause pruritus. Primary Biliary Cirrhosis (PBC), cholestasis during pregnancy (pruritus gravidarum), drug-induced cholestasis, and viral hepatitis are all intrahepatic cholestasis processes linked to pruritus.
Cholestatic Pruritus Pipeline Analysis: Drug Profile
GSK2330672: GlaxoSmithKline
Product Description
GSK2330672 is a human IBAT selective inhibitor that is designed to be a non-absorbable drug that is limited to the gastrointestinal (GI) tract. The company has completed Phase II of clinical development, and phase III trials are currently underway.
Research and Development in the Cholestatic Pruritus Pipeline Landscape
Phase III
NCT04167358: GlaxoSmithKline began a study called “Long-term Safety and Tolerability Study with Linerixibat for the Treatment of Cholestatic Pruritus in Participants With Primary Biliary Cholangitis” in July 2020. The trial is presently recruiting volunteers, with a target participation of 75 people, and it is set to end in December 2024.
Cholestatic Pruritus Pipeline Therapies and Key Companies
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LUM001: Mirum Pharmaceuticals
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GSK2330672: GlaxoSmithKline
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Seladelpar: CymaBay Therapeutics
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Korsuva: Cara Therapeutics
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EP 547: Escient Pharmaceuticals
Learn more about Cholestatic Pruritus @ Cholestatic Pruritus Pipeline Therapies and Key Companies
Cholestatic Pruritus Therapeutics Assessment
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By Product Type
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Monotherapy
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Combination Therapy
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By Stage
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Discovery
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Pre-Clinical
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Phase I
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Phase II
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Phase III
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Pre-registration
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By Route of Administration
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Inhalation
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Intravenous
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Oral
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Subcutaneous
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By Molecule Type
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Small Molecule
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Stem Cell Therapy
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Gene Therapy
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Targets
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Immune System
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Multiple Kinase
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Protease
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By Mechanism of Action
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Protease Inhibitors
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Immunomodulatory
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Multiple Kinase Inhibitors
Scope of the Report
Coverage: Global
Cholestatic Pruritus Key Players: Mirum Pharmaceuticals, GlaxoSmithKline, CymaBay Therapeutics, Cara Therapeutics, Escient Pharmaceuticals, among others
Cholestatic Pruritus Pipeline Therapies: LUM001, GSK2330672, Seladelpar, Korsuva, EP 547, and others
Table of Contents
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1. |
Introduction |
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2. |
Executive Summary |
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3. |
Cholestatic Pruritus: Overview |
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4. |
Cholestatic Pruritus- Analytical Perspective In-depth Commercial Assessment |
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5. |
Cholestatic Pruritus Pipeline Therapeutics |
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6. |
Cholestatic Pruritus Late Stage Products (Pre-Registration) |
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7. |
Cholestatic Pruritus Late Stage Products (Phase III) |
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8. |
Cholestatic Pruritus Mid Stage Products (Phase II) |
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9. |
Cholestatic Pruritus Early Stage Products (Phase I) |
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10. |
Cholestatic Pruritus Therapeutic Assessment |
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11. |
Cholestatic Pruritus Inactive Products |
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12. |
Cholestatic Pruritus Company-University Collaborations (Licensing/Partnering) Analysis |
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13. |
Cholestatic Pruritus Key Companies |
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14. |
Cholestatic Pruritus Key Products |
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15. |
Cholestatic Pruritus- Unmet Needs |
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16. |
Cholestatic Pruritus- Market Drivers and Barriers |
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17. |
Cholestatic Pruritus- Future Perspectives and Conclusion |
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18. |
Cholestatic Pruritus Analyst Views |
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19. |
Appendix |
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Key questions answered in the Cholestatic Pruritus Pipeline Report
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What are the treatment options for Cholestatic Pruritus?
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How many companies are working on Cholestatic Pruritus treatments?
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Which of these companies’ medicines is the most widely used?
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How many Cholestatic Pruritus medicines has each company generated in total?
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How many innovative therapies for Cholestatic Pruritus are being developed in the early, mid, and late stages?
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How many of the drugs under development can be used alone or in combination with other treatments?
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What are the most important industry-industry and industry-academy collaborations, mergers and acquisitions, and licencing practises that will affect Cholestatic Pruritus?
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