Peripheral Nerve Injuries comprises of various reversible and irreversible nerve impairments due to traumatic nerve injuries. People with Peripheral Nerve Injuries can experience severe pain, tingling, burning sensation, or loss of sensation in the affected part of the body.
The diagnosis of PNI in acute trauma cases is often ignored. Most of the nerve injuries are of mixed grade, and there is no diagnostic test to discriminate between Sunderland grades II and IV except histological examination.
A better understanding of the pathophysiology of PNI is crucial to ensure proper management. More in-depth studies on the pathophysiology of PNI and targeted research of the effective treatments are required to improve poor outcomes of the patients and reduce the related morbidity of PNI.
There is an immediate need for better selective therapy for the treatment of PNI, yet the drugs currently in the development are quite less and mostly comprise of the nerve repair devices. The approved products include conduits and nerve grafts. No drug or biologics is yet approved that have the potential to increase nerve repair and regeneration. There are only a few drugs anticipated to get launched by 2030.
Peripheral Nerve Injuries Market Insight
Peripheral Nerve Injuries market size in 7MM in 2017 was USD 2,182.82 million
Peripheral Nerve Injuries Market Drivers
- High incidence of nerve injuries
- Availability of technologically advanced nerve repair and regeneration products
- Research and Development
Peripheral Nerve Injuries Market Barriers
- Delayed and underdiagnosis
- Lack of epidemiological studies
- Limited understanding of the pathophysiology of Peripheral Nerve Injuries and repair
- Lack of approved therapies and weak clinical pipeline
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Table of contents
1. Key Insights
2. Executive Summary of Peripheral Nerve Injuries (PNI)
3. Peripheral Nerve Injuries Market Overview at a Glance
3.1. Market Share (%) Distribution of PNI in 2017
3.2. Market Share (%) Distribution of PNI in 2030
4. Disease Background and Overview: Peripheral Nerve Injuries (PNI)
4.1. Introduction
4.2. Peripheral nerves and their Injuries
4.3. Causes of PNI
4.4. Symptoms of PNI
4.5. Grading of PNI
4.6. Pathophysiology of Nerve Injury
4.7. Mechanism of PNI
4.8. Diagnosis of PNI
4.9. PNI guidelines (NHS)
5. Case Reports
5.1. Case presentation for peripheral nerve neuropraxia (trauma)
5.2. A case report of a long-term abandoned torn lingual nerve injury repaired by collagen nerve graft induced by lower third molar extraction
5.3. Peripheral nerve injury associated with a sub dermal contraceptive implant: illustrative cases and systematic review of literature
6. Epidemiology and Patient Population
6.1. Key Findings
6.2. KOL Views
6.3. Epidemiology Methodology
6.4. Total Number of Annual Peripheral Nerve Injuries (PNI) in the 7MM
6.5. Total Annual Number of PNI by extremities in the 7MM
6.6. Total Number of PNI Surgeries Performed in the 7MM
7. United States Epidemiology
7.1. Assumptions and Rationale
7.2. Total Number of Annual Peripheral Nerve Injuries in the United States
7.3. Total Annual Number of PNI by extremities in the United States
7.4. Total Number of PNI Surgeries Performed in the United States
8. EU5 Epidemiology
8.1. Germany Epidemiology
8.1.1. Assumptions and Rationale
8.1.2. Total Number of Annual Peripheral Nerve Injuries in Germany
8.1.3. Total Annual Number of PNI by extremities in Germany
8.1.4. Total Number of PNI Surgeries Performed in Germany
8.2. France Epidemiology
8.2.1. Assumptions and Rationale
8.2.2. Total Number of Annual Peripheral Nerve Injuries in France
8.2.3. Total Annual Number of PNI by extremities in France
8.2.4. Total Number of PNI Surgeries Performed in France
8.3. Italy Epidemiology
8.3.1. Assumptions and Rationale
8.3.2. Total Number of Annual Peripheral Nerve Injuries in Italy
8.3.3. Total Annual Number of PNI by extremities in Italy
8.3.4. Total Number of PNI Surgeries Performed in Italy
8.4. Spain Epidemiology
8.4.1. Assumptions and Rationale
8.4.2. Total Number of Annual Peripheral Nerve Injuries in Spain
8.4.3. Total Annual Number of PNI by extremities in Italy
8.4.4. Total Number of PNI Surgeries Performed in Spain
8.5. United Kingdom Epidemiology
8.5.1. Assumptions and Rationale
8.5.2. Total Number of Annual Peripheral Nerve Injuries in the United Kingdom
8.5.3. Total Annual Number of PNI by extremities in the United Kingdom
8.5.4. Total Number of PNI Surgeries Performed in the United Kingdom
9. Japan Epidemiology
9.1. Assumptions and Rationale
9.2. Total Number of Annual Peripheral Nerve Injuries in Japan
9.3. Total Annual Number of PNI by extremities in Japan
9.4. Total Number of PNI Surgeries Performed in Japan
10. Treatment
10.1. Surgical Approaches
10.2. Non-surgical therapeutic approaches for nerve recovery
10.3. Transcutaneous electrical nerve stimulation (TENS)
11. Unmet needs
12. Marketed Drugs
12.1. Key Cross
12.2. Nerbridge: Toyobo
12.2.1. Product Description
12.2.2. Other Developmental Activities
12.2.3. Safety and Efficacy
12.2.4. Product Profile
12.3. Neurolac and Neurolac Thin Wall (TW): Polyganics
12.3.1. Product Description
12.3.2. Regulatory Milestones
12.3.3. Other Developmental Activities
12.3.4. Clinical Development
12.3.5. Safety and Efficacy
12.3.6. Product Profile
12.4. Avance Nerve Graft: Axogen Corporation
12.4.1. Product Description
12.4.2. Regulatory Milestones
12.4.3. Other Developmental Activities
12.4.4. Clinical Development
12.4.5. Safety and Efficacy
12.4.6. Product Profile
13. Emerging Drugs
13.1. NTX-001: Neuraptive Therapeutics
13.1.1. Product Description
13.1.2. Other Developmental Activities
13.1.3. Clinical Development
13.1.4. Product Profile
13.2. SilkBridge: Silk Biomaterials
13.2.1. Product Description
13.2.2. Other Developmental Activities
13.2.3. Clinical Development
13.2.4. Safety and Efficacy
13.2.5. Product Profile
13.3. CelGro: Orthocell Limited
13.3.1. Product Description
13.3.2. Other Developmental Activities
13.3.3. Clinical Development
13.3.4. Safety and Efficacy
13.3.5. Product Profile
14. Peripheral Nerve Injuries (PNI): 7MM Market Analysis
14.1. Key Findings
14.2. Market Methodology
14.3. Market Size of Peripheral Nerve Injuries (PNI) in the 7MM
14.4. Market Size of Peripheral Nerve Injuries (PNI) by Techniques in the 7MM
15. Seven Major Market Outlook
16. United States Market Size
16.1. United States Market Size
16.1.1. Total market size of Peripheral Nerve Injuries (PNI) in the United States
16.1.2. Market Size of Peripheral Nerve Injuries (PNI) by Techniques in the US
17. EU-5 Market Size
17.1. Germany Market Size
17.1.1. Total Market size of Peripheral Nerve Injuries (PNI) in Germany
17.1.2. Market Size of Peripheral Nerve Injuries (PNI) by Techniques in Germany
17.2. France Market Size
17.2.1. Total Market size of Peripheral Nerve Injuries (PNI) in France
17.2.2. Market Size of Peripheral Nerve Injuries (PNI) by Techniques in France
17.3. Italy Market Size
17.3.1. Total Market size of Peripheral Nerve Injuries (PNI) in Italy
17.3.2. Market Size of Peripheral Nerve Injuries (PNI) by Techniques in Italy
17.4. Spain Market Size
17.4.1. Total Market size of Peripheral Nerve Injuries (PNI) in Spain
17.4.2. Market Size of Peripheral Nerve Injuries (PNI) by Techniques in Spain
17.5. United Kingdom Market Size
17.5.1. Total Market size of Peripheral Nerve Injuries (PNI) in the United Kingdom
17.5.2. Market Size of Peripheral Nerve Injuries (PNI) by Techniques in the UK
18. Japan Market Size
18.1. Japan Market Size
18.1.1. Total Market size of Peripheral Nerve Injuries (PNI) in Japan
18.1.2. Market Size of Peripheral Nerve Injuries (PNI) by Techniques in Japan
19. Market Drivers
20. Market Barriers
21. SWOT Analysis
22. Reimbursement and Market Access
23. Appendix
23.1. Bibliography
23.2. Report Methodology
24. DelveInsight Capabilities
25. Disclaimer
26. About DelveInsight
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